[Chromosomes of 3 lymphoblastoid suspension cell lines obtained from baboons with malignant lymphoma]

Autor: D S, Markarian, I A, Gvaramiia, V Z, Agrba, I A, Sanguliia
Rok vydání: 1977
Předmět:
Zdroj: Tsitologiia. 19(2)
ISSN: 0041-3771
Popis: Three suspension cell lines from bone marrow (BMPH-1) and spleens (SPH-2 and SPH-3) of hamadryas baboons with haematosarcoma were presented by analogous lymphoid type cells of a high proliferative activity. The modal class of cells in all the three lines was presented by diploids and pseudodiploids, though there was a significant admixture of heterodiploid and subtriploid cells and cells having various types of marker chromosomes. The reconstructed chromosome 1 and satellite chromosomes dominated among the marker chromosomes indicating their relatively greater mutability. No change was observed in Giemsa-banding during a year's cultivation of all three cell lines. The total number of weakly and poorly differentiating chromosomes in aneuploids is more variable compared to the number of well differentiating chromosomes, due, presumably, to a lesser biological significance of the former.
Databáze: OpenAIRE