Amplified canonical transforming growth factor-β signalling
| Autor: | Zaneta, Sibinska, Xia, Tian, Martina, Korfei, Baktybek, Kojonazarov, Janina Susanne, Kolb, Walter, Klepetko, Djuro, Kosanovic, Malgorzata, Wygrecka, Hossein Ardeschir, Ghofrani, Norbert, Weissmann, Friedrich, Grimminger, Werner, Seeger, Andreas, Guenther, Ralph T, Schermuly |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Epithelial-Mesenchymal Transition Lactams Macrocyclic Fibroblasts Idiopathic Pulmonary Fibrosis Extracellular Matrix Mice Inbred C57BL Bleomycin Mice A549 Cells Transforming Growth Factor beta Cell Transdifferentiation Benzoquinones Animals Humans Immunoprecipitation HSP90 Heat-Shock Proteins Lung Signal Transduction |
| Zdroj: | The European respiratory journal. 49(2) |
| ISSN: | 1399-3003 |
| Popis: | Interstitial lung fibroblast activation coupled with extracellular matrix production is a pathological signature of idiopathic pulmonary fibrosis (IPF), and is governed by transforming growth factor (TGF)-β/Smad signalling. We sought to define the role of heat shock protein (HSP)90 in profibrotic responses in IPF and to determine the therapeutic effects of HSP90 inhibition in a murine model of pulmonary fibrosis.We investigated the effects of HSP90 inhibition |
| Databáze: | OpenAIRE |
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