| Autor: |
A D, Ottolenghi, J K, Haseman, W W, Payne, H L, Falk, H N, MacFarland |
| Rok vydání: |
1975 |
| Předmět: |
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| Zdroj: |
Journal of the National Cancer Institute. 54(5) |
| ISSN: |
0027-8874 |
| Popis: |
Two hundred twenty-six specific pathogenfree male and female F344 rats were exposed to nickel sulfide inhalations for 78 weeks (5 days/wk, 6 hr/day) and observed for an adiditional 30-week period. For the same amount of time, 214 rats were exposed to filtered room air and served as controls. Rats exposed to nickel sulfide showed a significantly higher incidence of pulmonary hyperplastic and neoplastic lesions originating from the bronchial and bronchiloo-alveloar segments. The overall incidence of lung tumors in the animals treated with nickel sulfide was 14 percent compared with 1 percent in the controls. Pulmonary inflammatory reactions were also greatly increased. Injection of an agent (hexachlorotetra-fluorobutane) that induced lung infarction did not increase the proportion of animals having lesions, nor did it alter the type of lesions found in animals exposed to nickel sulfide. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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