| Autor: |
N V, Bovin, T V, Zemlianukhina, A Ia, Khorlin |
| Rok vydání: |
1986 |
| Předmět: |
|
| Zdroj: |
Bioorganicheskaia khimiia. 12(4) |
| ISSN: |
0132-3423 |
| Popis: |
Bioside Gal beta 1-3GalNAc alpha 1-O(CH2)3NHCOCF3 has been synthesized. The key alpha-glycoside GalNAc alpha 1-O(CH2)3NHCOCF3 (peracetate) was obtained either by isomerization of its beta-anomer with trifluoromethanesulfonic acid, or by direct glycosylation of 3-(trifluoroacetamido)propanol with D-galactosamine (anomeric pentaacetate) in the presence of a mixture of trifluoromethanesulfonic acid and boron trifluoride etherate. De-O-acetylated alpha-galactosaminide obtained was further transformed into benzylidene derivative, the latter was glycosylated with acetobromogalactose to give the protected alpha-bioside. The removal of the protecting groups gave the (3-aminopropyl)-alpha-bioside, which was subsequently immobilized on bovine serum albumin and cytochrome c. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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