A prospective, multicenter head-to-head comparative study in patients with primary high-risk prostate cancer investigating the bone lesion detection of conventional imaging and

Autor: Y J L, Bodar, W I, Luining, B, Keizer, D, Meijer, A, Vellekoop, M, Schaaf, N H, Hendrikse, R J A, Van Moorselaar, D E, Oprea-Lager, A N, Vis
Rok vydání: 2022
Zdroj: Urologic oncology.
ISSN: 1873-2496
Popis: Prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) is an emerging staging tool for patients with primary high-risk prostate cancer (PCa). Patients with primary metastatic disease are staged using PSMA-PET/CT imaging, while previously published randomized clinical trials relied on conventional imaging (i.e., bone scintigraphy (BS) results. The aim of this study was to compare the ability of bone metastatic lesion detection and changes in staging for79 patients with high-risk PCa were prospectively staged using BS and subsequentA change of CHAARTED risk group was observed in 9/70 (12.8%) of patients in Group 1. In Group 2, a change of risk group was found in 66.7% of patients, due to either upstaging (4/9 patients (44.4%)) and downstaging (2/9 patients (22.2%)). Treatment changes due to use of a different imaging modality occurred in almost 20% of patients.In patients with negative for cancer results on BS, upstaging on
Databáze: OpenAIRE
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