| Autor: |
Jenna C, Carlson, Mohanraj, Krishnan, Samantha L, Rosenthal, Emily M, Russell, Jerry Z, Zhang, Nicola L, Hawley, Jaye, Moors, Hong, Cheng, Nicola, Dalbeth, Janak R, de Zoysa, Huti, Watson, Muhammad, Qasim, Rinki, Murphy, Take, Naseri, Muagututi'a Sefuiva, Reupena, Satupa'itea, Viali, Lisa K, Stamp, John, Tuitele, Erin E, Kershaw, Ranjan, Deka, Stephen T, McGarvey, Tony R, Merriman, Daniel E, Weeks, Ryan L, Minster |
| Rok vydání: |
2022 |
| Zdroj: |
HGG advances. 4(1) |
| ISSN: |
2666-2477 |
| Popis: |
Current understanding of lipid genetics has come mainly from studies in European-ancestry populations; limited effort has focused on Polynesian populations, whose unique population history and high prevalence of dyslipidemia may provide insight into the biological foundations of variation in lipid levels. Here, we performed an association study to fine map a suggestive association on 5q35 with high-density lipoprotein cholesterol (HDL-C) seen in Micronesian and Polynesian populations. Fine-mapping analyses in a cohort of 2,851 Samoan adults highlighted an association between a stop-gain variant (rs200884524; c.652CT, p.R218∗; posterior probability = 0.9987) in |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
