| Autor: |
M D, Trus, J G, Sodroski, W A, Haseltine |
| Rok vydání: |
1982 |
| Předmět: |
|
| Zdroj: |
The Journal of biological chemistry. 257(6) |
| ISSN: |
0021-9258 |
| Popis: |
A single locus (designated c-fes) in the human genome which exhibits homology to the transformation-specific onc gene (v-fes) of Snyder-Theilen feline sarcoma virus was identified by the Southern blot technique. Recombinant clones containing 16- to 18-kilobase inserts of human DNA including the c-fes locus were constructed. Restriction endonuclease mapping of these clones verified their identity with native human c-fes and demonstrated the presence of at least two sequences in human c-fes interrupting v-fes-homologous regions. The v-fes-homologous locus in the human genome spans about 4 kilobases. The 5'-3' orientation of the c-fes clones with respect to feline sarcoma virus proviral DNA was determined. The region of the human genome that is homologous to v-fes is proximal to the highly reiterated human Alu sequence but not to the highly reiterated human alphoid sequence. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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