| Autor: |
Thorya S, El-Deeb, Sally M, Bakkar, Lobna, Eltoony, Madeha M, Zakhary, Amira A, Kamel, Amany M, Nafee, Helal F, Hetta |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
The Egyptian journal of immunology. 25(1) |
| ISSN: |
1110-4902 |
| Popis: |
Chemerin and fetuin-A are recently discovered as metabolic regulator hormone in obesity and type 2 diabetes mellitus. However, elevated levels of chemerin and fetuin-A have been associated with insulin resistance and systemic inflammation. The present study aimed to investigate the significance of serum chemerin and fetuin-A levels in obese diabetic patients. Also, to determine whether, chemerin and fetuin-A along with markers of inflammation (IL6 and CRP) and obesity-related parameters in T2DM patients. Serum levels of chemerin and fetuin-A were evaluated using ELISA in 71 T2DM patients and 14 apparently healthy controls. Both groups were subdivided into obese and lean. Serum chemerin and fetuin-A levels were significantly higher in T2DM patients compared to controls (P0.001, for both) and significantly higher in obese T2DM in comparison to obese control group (P0.01P0.05, respectively). Serum chemerin and fetuin-A levels correlated positively with HbA1c, HOMA-IR, FBG, IL6 and CRP. In obese patients, serum chemerin and fetuin-A levels correlated positively with BMI and waist circumference. In conclusion, the strong association of chemerin and fetuin-A with insulin resistance and some inflammatory markers may provide an interesting link between obesity, inflammation and diabetes mellitus in human. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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