| Autor: |
Edith, Labos, Sofía, Trojanowski, Marcelo, Schapira, Daniel, Seinhart, Alejandro, Renato |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
Vertex (Buenos Aires, Argentina). (129) |
| ISSN: |
0327-6139 |
| Popis: |
The Memory Impairment Screen (MIS-A) is a validated test to detect Alzheimer's Disease (AD) and other dementias. We have modified this test to suit a Spanish speaking population and added a new component, delayed recall (MIS-D).1) To test a Spanish version of MIS-A and MIS-D. 2) To assess the discriminative validity of MIS-D as a screening tool for the amnestic variant of Mild Cognitive Impairment (aMCI).A case-control study of a cohort of 739 aged 65 years old and over, of whom 436 were healthy controls and 303 had a diagnosis of aMCI. The MCI group was patients from the Geriatric Unit for the Elderly at the Italian Hospital of Buenos Aires staffed by geriatricians.ANOVA test and test t de Student mean comparison. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NVP) were estimated for MIS-D and MIS-A.Normative values for MIS-A and MIS-D were obtained from the control population. Both age and education significantly affected these values (p0.0001). The cut-off for MIS-A should be 7.5 and for MIS-D, 5.5. Comparison between control population and aMCI population using ROC curve gave a result of 5.5 in MIS-D, with 97% specificity and 76% sensitivity.MIS-D was positively predictive of Amci. An extension of the sample in other health care contexts would enable us to verify its clinical validity for other populations. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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