| Autor: |
Bao-lin, Shi, Yong, Zhang, Yan-hua, Wu, Jie, Zhang |
| Rok vydání: |
2003 |
| Předmět: |
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| Zdroj: |
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi. 24(8) |
| ISSN: |
0254-6450 |
| Popis: |
To explore the genetic model of cerebral infarction and to examine the relationship between cerebral infarction and genetic factor.A matched case-control study including 112 pairs pedigrees was carried out. Using the Li-Mantel-Gart method and the Falconer method to estimate the segregation ratio and the heritability of cerebral infarction.The prevalence rate of the first-degree and the second-degree relatives in cases was significantly higher than that in controls. The segregation ratio was 0.143 7 (0.113 0 - 0.174 4), significantly lower than 0.25, which showed that cerebral infarction did not possess the characteristics of monogenetic model. The results showed that the heritability of the first-degree and the second-degree relatives were 47.84% and 40.95% higher in male's than in female's.Cerebral infarction was a polygenetic disease, and the genetic factors played an important role in the occurrence of cerebral infarction, especially in males. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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