Anti-hypertensive effect of Lycium barbarum L. with down-regulated expression of renal endothelial lncRNA sONE in a rat model of salt-sensitive hypertension
| Autor: | Zhang, Xinyu, Yang, Xinping, Lin, Yahui, Suo, Miaomiao, Gong, Ling, Chen, Jingzhou, Hui, Rutai |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Plants Medicinal Time Factors Nitric Oxide Synthase Type III Plant Extracts Down-Regulation Endothelial Cells Blood Pressure Lycium Kidney Disease Models Animal Rats Inbred SHR Hypertension Human Umbilical Vein Endothelial Cells Animals Original Article Female RNA Long Noncoding Rats Wistar Sodium Chloride Dietary Antihypertensive Agents Cells Cultured Crosses Genetic Phytotherapy |
| Popis: | The present study aims to test whether Lycium barbarum L. has anti-hypertensive effect through regulating expression of lncRNA sONE in a rat model of salt-sensitive hypertension. Nine weeks old borderline hypertensive rats (BHRs) were divided into 4 groups receiving high (8% NaCl), medium (0.25% NaCl, as control group), and low salt diet (0.015% NaCl) for 16 weeks, respectively, while the fourth group (high salt + L. barbarum group) fed with high salt diet for 12 weeks, then followed by 8% NaCl and L. barbarum treatment for 4 weeks. Body weight and blood pressure were recorded biweekly. Salt-sensitive hypertension was successfully induced by 12-week high salt diet in BHR model. Blood pressure was significantly increased in the model (P < 0.05), and L. barbarum treatment reversed the elevated blood pressure to normal level. Expression of lncRNA sONE was significantly reduced and eNOS expression level was dramatically improved in the hypertension model rats with the L. barbarum compared with that receiving high salt diet. Our results indicated that L. barbarum L. had anti-hypertensive effect and might lower blood pressure by suppressing the expression of lncRNA sONE in BHR model. |
| Databáze: | OpenAIRE |
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