| Autor: |
Ting, Yang, Shi, Yang, Tasdiq, Ahmed, Katherine, Nguyen, Jinlong, Yu, Xuejun, Cao, Rui, Zan, Xiaonong, Zhang, Hao, Shen, Meredith E, Fay, Evelyn Kendall, Williams, Wilbur A, Lam, J Scott, VanEpps, Shuichi, Takayama, Yang, Song |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Adv Mater Interfaces |
| ISSN: |
2196-7350 |
| Popis: |
Neutrophil extracellular traps (NETs) is an antimicrobial cobweb-structured material produced by immune cells for clearance of pathogens in the body, but paradoxically associated with biofilm formation and exacerbated lung infections. To provide a better materials perspective on the pleiotropic roles played by NETs at diverse compositions/concentrations, a NETs-like material (called ‘microwebs’, abbreviated as μwebs) is synthesized for decoding the antimicrobial activity of NETs against Staphylococcus aureus in infection-relevant conditions. We show that μwebs composed of low-to-intermediate concentrations of DNA-histone complexes successfully trap and inhibit S. aureus growth and biofilm formation. However, with growing concentrations and histone proportions, the resulting microwebs appear gel-like structures accompanied by reduced antimicrobial activity that can even promote formation of S. aureus biofilms. Our simplified model of NETs provides a materials-based evidence on NETs-relevant pathology in the development of biofilms. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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