Effect of somatostatin on thyrotropin, prolactin, growth hormone and insulin responses to thyrotropin releasing hormone and arginine in healthy, hypothyroid and acromegalic subjects
| Autor: | Faure, N., Dussault, J. H., Nadeau, A., Szots, F., Guyda, H., Labrie, F. |
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| Jazyk: | angličtina |
| Rok vydání: | 1977 |
| Předmět: |
Adult
Male endocrine system endocrine system diseases Thyrotropin Middle Aged Arginine Prolactin Hypothyroidism Growth Hormone Acromegaly Insulin Secretion Humans Insulin Female Secretory Rate Somatostatin Thyrotropin-Releasing Hormone hormones hormone substitutes and hormone antagonists Research Article |
| Popis: | The effect of somatostatin on the thyrotropin (TSH), prolactin, growth hormone (GH) and insulin responses to the combined administration of thyrotropin releasing hormone (TRH) and arginine was studied in six healthy subjects, three hypothyroid patients and three acromegalic patients. Similar inhibition by somatostatin of the TSH and insulin responses was observed in the three groups. While the tetradecapeptide had no significant effect on the prolactin response in the healthy and acromegalic subjects, it caused an unexpected inhibition of the prolactin response in two of the hypothyroid subjects. Contrary to the findings in the healthy and hypothyroid subjects, somatostatin did not inhibit the GH response in the acromegalic patients. Normal inhibition by somatostatin of the insulin response, followed by a rebound in insulin secretion, was observed in all subjects. These preliminary data indicate increased sensitivity of the prolactin-secreting cells to somatostatin in hypothyroidism and suggest that decreased responsiveness of the somatotrophs to somatostatin could play a role in the pathogenesis of acromegaly. |
| Databáze: | OpenAIRE |
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