Healing of a tibial double osteotomy is modified by clodronate administration

Autor:	M T, Nyman, T, Gao, T C, Lindholm, T S, Lindholm
Rok vydání:	1996
Předmět:	Fracture Healing Male Radiography Disease Models Animal Fractures Open Calcification Physiologic Animals Rats Inbred Strains Clodronic Acid Administration Cutaneous Osteotomy Rats
Zdroj:	Archives of orthopaedic and trauma surgery. 115(2)
ISSN:	0936-8051
Popis:	We studied the healing of tibial double osteotomies in rats during clodronate administration 10 mg/kg daily subcutaneously for 6 weeks. Clodronate treatment did not inhibit the endochondral bone formation in callus or in the epiphyseal plate. The differentiation of osteoblasts into mature osteocytes was disturbed, and the bone structure around the osteocytes was not normal. In the clodronate-treated group, the amount of newly formed bone matrix seemed increased, but mineralization of the bone matrix was delayed. The bundle bone trabeculae in callus were not so spatially well organized as in the controls. No delay in the union of the bone segment by new bone was seen during clodronate administration.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::370755fdb42b9be368fbd353e39e718a https://pubmed.ncbi.nlm.nih.gov/9063849 Zobrazit plný text záznamu Full text from SpringerLink