| Autor: |
Sebastian, Radej, Paweł, Płaza, Alina, Olender, Monika, Szewc, Krzysztof, Bar, Ryszard, Maciejewski |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Research and Reports in Urology |
| ISSN: |
2253-2447 |
| Popis: |
Purpose The aim of the study was to evaluate prostate cell infiltration by CD4(+)IL-17(+) and Treg cells in BPH and PCa patients depending on P. acnes infection in the prostate gland. Patients and Methods Prostate fragments were collected from 54 patients with PCa and 34 patients with BPH. Rapid ID 32 was used to identify the bacteria. Cells were analyzed by flow cytometry BD FACSCanto II. Statistical analysis was performed using Statistica 7 software (TIBCO Software Inc, USA). Results P. acnes was detected in 35% of patients with PCa and 41% of individuals with BPH. The infiltration of CD4(+)IL-17(+) and Treg cells was statistically significantly higher (P = 0.001) in patients with BPH and positive for P. acnes. A statistically considerably higher (P = 0.001) infiltration of Treg cells in treated for PCa with P.acnes infection was also demonstrated. Conclusion Prostatitis caused by P. acnes may contribute to the development of BPH and PCa. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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