Leucocytoclastic vasculitis induced by prolonged exercise

Autor:	M, Prins, J C, Veraart, A H, Vermeulen, R F, Hulsmans, H A, Neumann
Rok vydání:	1996
Předmět:	Male Immunoglobulin M Erythema Complement C3c Humans Vasculitis Leukocytoclastic Cutaneous Female Walking Leg Dermatoses Purpura
Zdroj:	The British journal of dermatology. 134(5)
ISSN:	0007-0963
Popis:	Many people develop skin symptoms after long-distance walks, but little is known about the aetiology of these. In this study we took 11 biopsies from 10 long-distance walkers who walked 80 km. All biopsies originated from purpuric lesions on the lower legs, which had appeared during walking. In all 11 specimens, signs of a leucocytoclastic vasculitis were present with leucocytoclasis, exocytosis of erythrocytes and a granulocyte/mononuclear perivascular infiltrate. Immunofluorescence investigations showed deposition of C3c in many specimens and immunoglobulin M in some. The occurrence of a leucocytoclastic vasculitis after prolonged exercise may be explained by the existence of an exercise altered cutaneous microcirculation, complement activation and an altered immune function.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::34761fc49c9d0482ddafdd85ac6a9188 https://pubmed.ncbi.nlm.nih.gov/8736335 Zobrazit plný text záznamu Plný text