A 19-SNP coronary heart disease gene score profile in subjects with type 2 diabetes: the coronary heart disease risk in type 2 diabetes (CoRDia study) study baseline characteristics
| Autor: | Katherine E, Beaney, Claire E, Ward, Dauda A S, Bappa, Nadine, McGale, Anna K, Davies, Shashivadan P, Hirani, KaWah, Li, Philip, Howard, Dwaine R, Vance, Martin A, Crockard, John V, Lamont, Stanton, Newman, Steve E, Humphries |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Genetic Markers Male Time Factors Coronary Artery Disease Polymorphism Single Nucleotide Risk Assessment UKPDS score Predictive Value of Tests Pregnancy Risk Factors Humans Genetic Predisposition to Disease Precision Medicine Genetic Association Studies Aged Oligonucleotide Array Sequence Analysis Original Investigation Gene Expression Profiling Type 2 diabetes Middle Aged United Kingdom Risk prediction Coronary heart disease Phenotype Diabetes Mellitus Type 2 Case-Control Studies Female Diabetic Angiopathies Gene score |
| Zdroj: | Cardiovascular Diabetology |
| ISSN: | 1475-2840 |
| Popis: | Background The coronary risk in diabetes (CoRDia) trial (n = 211) compares the effectiveness of usual diabetes care with a self-management intervention (SMI), with and without personalised risk information (including genetics), on clinical and behavioural outcomes. Here we present an assessment of randomisation, the cardiac risk genotyping assay, and the genetic characteristics of the recruits. Methods Ten-year coronary heart disease (CHD) risk was calculated using the UKPDS score. Genetic CHD risk was determined by genotyping 19 single nucleotide polymorphisms (SNPs) using Randox’s Cardiac Risk Prediction Array and calculating a gene score (GS). Accuracy of the array was assessed by genotyping a subset of pre-genotyped samples (n = 185). Results Overall, 10-year CHD risk ranged from 2–72 % but did not differ between the randomisation groups (p = 0.13). The array results were 99.8 % concordant with the pre-determined genotypes. The GS did not differ between the Caucasian participants in the CoRDia SMI plus risk group (n = 66) (p = 0.80) and a sample of UK healthy men (n = 1360). The GS was also associated with LDL-cholesterol (p = 0.05) and family history (p = 0.03) in a sample of UK healthy men (n = 1360). Conclusions CHD risk is high in this group of T2D subjects. The risk array is an accurate genotyping assay, and is suitable for estimating an individual’s genetic CHD risk. Trial registration This study has been registered at ClinicalTrials.gov; registration identifier NCT01891786 |
| Databáze: | OpenAIRE |
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