Utility of a multiple serum biomarker test to monitor remission status and relapse in dogs with lymphoma undergoing treatment with chemotherapy

Autor:	I, Alexandrakis, R, Tuli, S C, Ractliffe, S W, Tappin, R D, Foale, A, Roos, K J, Slater
Rok vydání:	2013
Předmět:	Male Haptoglobins Lymphoma Remission Induction Prognosis C-Reactive Protein Dogs Antineoplastic Combined Chemotherapy Protocols Multivariate Analysis Biomarkers Tumor Animals Female Dog Diseases Neoplasm Recurrence Local Algorithms Netherlands Retrospective Studies
Zdroj:	Veterinary and comparative oncology. 15(1)
ISSN:	1476-5829
Popis:	A blinded retrospective study was conducted to investigate remission and recurrence of lymphoma in dogs receiving chemotherapy. The objective was to compare clinicians' assessment using palpation and cytology to the results of serum biochemical tests for haptoglobin (Hapt) and C-reactive protein (C-RP). These biochemical test results were combined using a diagnostic algorithm developed using data from 344 individual dogs. This multivariate approach, termed the canine lymphoma blood test (cLBT), was used to follow 57 dogs during and after treatment. cLBT of remission and recurrence compared well with clinicians' assessment and differentiated dogs in remission and those with recurring disease before appearance of lymphadenopathy (P 0.001). The cLBT demonstrated prognostic potential based on pre-treatment values on dogs with shorter survival times and on those achieving the lowest cLBT score during treatment that showed longer survival times. The test, therefore, demonstrates potential to assist in monitoring treatment of canine lymphoma.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::32b02c89e9875f9fcf02b222f873b911 https://pubmed.ncbi.nlm.nih.gov/25319380 Zobrazit plný text záznamu Plný text