12-Oxo-10-glutathionyl-5,8,14-eicosatrienoic acid (TOG

Autor: Stefanie, Liening, Jana, Fischer, Hans, Jagusch, Georg, Pohnert, Oliver, Höcker, Christian, Neusüß, Oliver, Werz, Gerhard K E, Scriba, Ulrike, Garscha
Rok vydání: 2020
Předmět:
Zdroj: Prostaglandinsother lipid mediators. 152
ISSN: 1098-8823
Popis: Biologically active glutathione (GSH) conjugates of oxygenated fatty acids comprise a group of pro- and anti-inflammatory lipid mediators. While arachidonic acid (AA)-derived conjugates, as the cysteinyl leukotrienes (cys-LTs) and eoxins (EXs) have pro-inflammatory properties, conjugates in tissue regeneration (CTRs) biosynthesized from docosahexaenoic acid (DHA) exhibit pro-resolving activity. Human platelets express abundant amounts of platelet-type 12-lipoxygenase (pt12-LOX) and leukotriene C
Databáze: OpenAIRE