Phase I 1/2 evaluation and methodology of RO 20-2230 in postoperative patients

Autor:	C R, Brown, F H, Sarnquist, C A, Canup
Rok vydání:	1979
Předmět:	Adult Male Analgesics Clinical Trials as Topic Pain Postoperative Morphinans Surveys and Questionnaires Drug Evaluation Humans Female Middle Aged
Zdroj:	Journal of clinical pharmacology. 19(2-3)
ISSN:	0091-2700
Popis:	This report presents the rationale and methodology of our "phase 1 1/2" model for drug evaluation and reports the results of a typical study. We found that Ro 20-2230, and investigational agonist-antagonist analgesic, was well tolerated in therapeutic doses, with 15 mg intramuscular Ro 20-2230 approximately equivalent to 10 mg intramuscular morphine sulfate.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::2d8da6033baa22f9588a0f492f459ef6 https://pubmed.ncbi.nlm.nih.gov/370156 Zobrazit plný text záznamu Plný text