| Autor: |
Junhua, Li, Cheng, Zhang, Hongrui, Xu, Chao, Wang, Ruibo, Dong, Hui, Shen, Xiaoxi, Zhuang, Xiaoshan, Chen, Qiu, Li, Jibu, Lu, Maofeng, Zhang, Xishan, Wu, Kerry M, Loomes, Yulai, Zhou, Yan, Zhang, Jinsong, Liu, Yong, Xu |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Journal of medicinal chemistry. 65(7) |
| ISSN: |
1520-4804 |
| Popis: |
Pan-bromodomain and extra terminal (Pan-BET) inhibitors show profound efficacy but exhibit pharmacology-driven toxicities in clinical trials. The development of domain-selective BET inhibitors to separate efficacy and toxicity is urgently needed. Herein, we report a series of furo[3,2 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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