HbA(1c) in adults without known diabetes from southern Europe. Impact of the new diagnostic criteria in clinical practice

Autor: M R, Bernal-Lopez, S, Santamaría-Fernandez, D, Lopez-Carmona, F J, Tinahones, J, Mancera-Romero, D, Peña-Jimenez, S, Jansen-Chaparro, A J, Baca-Osorio, A L, Cuesta-Muñoz, M, Serrano-Rios, R, Gomez-Huelgas
Rok vydání: 2011
Předmět:
Zdroj: Diabetic medicine : a journal of the British Diabetic Association. 28(11)
ISSN: 1464-5491
Popis: To analyse the differences in the prevalence of diabetes and dysglycaemia using fasting plasma glucose and HbA(1c) criteria.Analytical cross-sectional study undertaken in a random sample of 2144 individuals (age 18-80 years) without known diabetes from the primary care setting in Malaga (Spain). Dysglycaemia was defined as fasting plasma glucose 5.6-6.9 mmol/l or HbA(1c) 39-46 mmol/mol (5.7-6.4%) and diabetes as fasting plasma glucose ≥ 7.0 mmol/l or HbA(1c)≥ 48 mmol/mol (≥ 6.5%).The proportion of subjects who were normoglycaemic was significantly higher using fasting plasma glucose than HbA(1c) (83.5 vs. 65%) (P0.0001). Compared with fasting plasma glucose, HbA(1c) detects more cases of dysglycaemia (32 vs. 14.8%) (P0.0001) and diabetes (3 vs. 1.7%) (P0.0001).In our environment, using HbA(1c) for the diagnosis of pre-diabetes and diabetes could increase the target population for preventive and therapeutic measures. Further cost-effectiveness studies are needed before the widespread diagnostic use of HbA(1c) can be recommended.
Databáze: OpenAIRE