N,N'-1,10-Bis(Naringin) Triethylenetetraamine, Synthesis and as a Cu(II) Chelator for Alzheimer's Disease Therapy

Autor:	Li-Xia, Guo, Bin, Sun
Rok vydání:	2020
Předmět:	Amyloid beta-Peptides Cell Survival Superoxide Dismutase PC12 Cells Trientine Antioxidants Peptide Fragments Rats Oxidative Stress Alzheimer Disease Flavanones Animals Reactive Oxygen Species Copper Chelating Agents
Zdroj:	Biologicalpharmaceutical bulletin. 44(1)
ISSN:	1347-5215
Popis:	The bis-Schiff base of N,N'-1,10-bis(naringin) triethylenetetraamine (1) was prepared, as a copper(II) ion chelator, compound 1 was used for Alzheimer's disease therapy in vitro. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay of compound 1 showed that this Schiff base could promote PC12 cells proliferation, and also, compound 1 could inhibit Cu
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::2bd8bb136caed9eb93a824d0366f2259 https://pubmed.ncbi.nlm.nih.gov/33162492 Zobrazit plný text záznamu