| Autor: |
Y S, Prabhakar, A K, Saxena, M J, Doss |
| Rok vydání: |
1989 |
| Předmět: |
|
| Zdroj: |
Drug design and delivery. 4(2) |
| ISSN: |
0884-2884 |
| Popis: |
The 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR) inhibitory activity of 7-(aryl/biphenyl)-6-heptenoic acids was quantitatively analysed using hydrophobicity, van der Waals volume and electronic parameters. The activity was primarily a function of hydrophobicity, and was well correlated with the hydrophobicity of ortho and meta substituents on the aryl/biphenyl moiety. The electronic properties of para substituents on the aryl/biphenyl ring influenced the inhibition. Our equations predict that substituents with positive polar and sigma and negative resonance constants might lead to better inhibition. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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