| Autor: |
Tanaka, Hideaki, Matsumoto, Hidenari, Takahashi, Haruya, Hosonuma, Masahiro, Sato, Shunya, Ogura, Kunihiro, Oishi, Yosuke, Masaki, Ryota, Sakai, Koshiro, Sekimoto, Teruo, Kondo, Seita, Tsujita, Hiroaki, Tsukamoto, Shigeto, Sumida, Arihiro, Okada, Natsumi, Inoue, Kazuo, Shinke, Toshiro |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
EuroIntervention |
| Popis: |
BACKGROUND: Caffeine intake from one cup of coffee one hour before adenosine stress tests, corresponding to serum caffeine levels of 3-4 mg/L, is thought to be acceptable for non-invasive imaging. AIMS: We aimed to elucidate whether serum caffeine is independently associated with adenosine-induced fractional flow reserve (FFR) overestimation and their concentration-response relationship. METHODS: FFR was measured using adenosine (FFR(ADN)) and papaverine (FFR(PAP)) in 209 patients. FFR(ADN) overestimation was defined as FFR(ADN) − FFR(PAP). The locally weighted scatterplot smoothing (LOWESS) approach was applied to evaluate the relationship between serum caffeine level and FFR(ADN) overestimation. Multiple regression analysis was used to determine independent factors associated with FFR(ADN) overestimation. RESULTS: Caffeine was ingested at 24 hours in 89 patients. Multiple regression analysis identified serum caffeine level as the strongest factor associated with FFR(ADN) overestimation (p24-hour groups corresponded to FFR(ADN) overestimations by 0.06, 0.03, and 0.02, respectively. CONCLUSIONS: Serum caffeine overestimates FFR(ADN) values in a linear concentration-response manner. FFR(ADN) overestimation occurs at much lower serum caffeine levels than those that were previously believed. Our results highlight that standardised caffeine control is required for reliable adenosine-induced FFR measurements. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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