| Autor: |
Sergey V, Ivanov, Ryan, Bauer, Elena N, Pokidysheva, Sergei P, Boudko |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Advances in experimental medicine and biology. 21 |
| ISSN: |
0065-2598 |
| Popis: |
Collagen molecules are crucial extracellular players in animal tissue development and in functions ranging from ultrafiltration to organism locomotion. Among the 28 types of collagen found in human, type IV collagen stands out as a primordial type found in all species of the animal kingdom. Collagen IV forms smart scaffolds for basement membranes, sheet-like acellular structures that isolate, coordinate, and direct cells during morphogenesis. Collagen IV is also involved in multiple functions in developed tissues. As part of the basement membrane, collagen IV scaffolds provide mechanical strength, spatially tether extracellular macromolecules and directly signal to cells via receptor binding sites. Proper assembly and structure of the scaffolds are critical for development and function of multiple types of basement membranes. Within last 5 years it was established that Cl |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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