An assessment of the distortion of arteries due to sectioning in endomyocardial biopsies

Autor:	J J, Boyle, J, Jenkins, I C, McKay, A R, McPhaden, G B, Lindop
Rok vydání:	1997
Předmět:	Postoperative Care Paraffin Embedding Biopsy Models Cardiovascular Heart Transplantation Humans Coronary Vessels Endocardium
Zdroj:	The Journal of pathology. 181(2)
ISSN:	0022-3417
Popis:	Arteries are usually studied morphometrically after pressurized fixation and resin embedding. These procedures are impracticable when dealing with diagnostic biopsies. The accuracy of arterial morphometry is determined partly by the degree of tissue distortion during section preparation. The axial ratios of 7340 arteries were measured in 353 endomyocardial biopsies from 23 patients and then compared with those expected from mathematical modelling. An excess of elliptical arteries was found. The distribution of orientation of the long axes of these best fitted a simulated 10 per cent linear distortion in the direction of microtomy. In conclusion, these results suggest that although there is some tissue distortion during sectioning, useful data may be obtained from morphometry of arteries in routinely processed endomyocardial biopsies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::27c08a71c33ff1c51bcde668c657e85a https://pubmed.ncbi.nlm.nih.gov/9120733 Zobrazit plný text záznamu Plný text