| Autor: |
Yajie, Su, Qiaolibang, Shadike, Mingbang, Wang, Haili, Jiang, Wanying, Liu, Jingfang, Liu, Rena, Tuerdi, Wenhao, Zhou, Long, Li |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Transl Pediatr |
| ISSN: |
2224-4344 |
| Popis: |
BACKGROUND: A low-phenylalanine (Phe) diet affects the metabolism and diversity of gut microbial communities in children with phenylketonuria (PKU). Our study examined gut microbiota characteristics and metabolic pathways, and their correlations with clinical phenotypes in a high-incidence population. METHODS: We assessed clinical phenotypes and gut microbiota by 16S ribosomal RNA (rRNA) sequencing, and performed a correlation analysis between phenotype and gut microbiota in a PKU group (n=11) and a healthy group (n=11). RESULTS: The PKU group had significantly lower microbiota diversity than the healthy group (P(shannon)=0.014). Phylum-level composition differed significantly between the PKU and healthy groups (Firmicutes: 44.3% vs. 43.1%; Actinobacteria: 25.9% vs. 3.3%; Bacteroidetes: 16.6% vs. 53.2%; and Proteobacteria: 10.9% vs. 0.12%, respectively). Further, a significantly decreased level of genus Bacteroidetes (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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