| Autor: |
Jiang-nan, Xue, Chun-yan, Wang, Xiao-shu, Zhang, Qi-zhi, Cao, Zhen-guo, Su |
| Rok vydání: |
2008 |
| Předmět: |
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| Zdroj: |
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 24(4) |
| ISSN: |
1007-8738 |
| Popis: |
To investigate the expression of LAIR-1 in patients with tumors and the function of LAIR-1 in anticancer immunity.A sandwich ELISA was employed to detect the serum sLAIR-1 from tumor patients and healthy individuals. The expression of LAIR-1 in CD4+ T cells, CD8+ T cells, NK cells and B cells isolated from the peripheral blood of cancer patients was examined by fluorescence staining and flow cytometry.The level of serum sLAIR-1 in tumor patients was higher than that in healthy individuals [4.6+/-3.2 microg/L vs 3.9+/-3.0 microg/L, P0.05]. NK cells, CD4+ T cells and CD8+ T cells expressed the up-regulated LAIR-1. The ratio of CD4/CD8 in lung cancer patients decreased significantly while the percentage of B cells in cancer patients increased greatly compared with healthy individuals.The expression of LAIR-1 is up-regulated in tumor patients, which may contribute to cancer immune escape. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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