| Autor: |
Hirofumi, Fukushima, Yasuhiko, Kubo, Satoru, Matsugaki, Ryosuke, Sakemi, Shigenari, Sakakibara, Yosuke, Morimitsu |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology. 116(11) |
| ISSN: |
0446-6586 |
| Popis: |
This case report presents two males with drug-induced liver injury acquired from working at a glass factory dealing with silica and 2,2-dichloro-1,1,1-trifluoroethane (HCFC-123). Within one month of work, both patients presented with fever, icterus with liver dysfunction, and eosinophilia. Case 1 had experienced recurrence of symptoms twice while working and showed positive results for the drug-induced lymphocyte stimulation test (DLST). Meanwhile, case 2 was diagnosed by liver biopsy and clinical course but was negative for DLST. Hazard of exposure to non-crystalline silica is low, but drug-induced liver injury after exposure to HCFC-123 has been reported. Allergic liver injury is also caused by chemical substances;however, the insight into whether this injury is caused by exposure to silica or HCFC-123 remains unclear. Further studies are required to examine the influence of silica and HCFC-123 on drug-induced liver injury among glass-factory employees. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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