| Autor: |
Trivedi, Meghna S., Colbeth, Hilary, Yi, Haeseung, Vanegas, Alejandro, Starck, Rebecca, Chung, Wendy K., Appelbaum, Paul S., Kukafka, Rita, Schechter, Isaac, Crew, Katherine D. |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Public Health Genomics |
| Popis: |
BACKGROUND/AIMS: Ashkenazi Jews have a 1:40 prevalence of BRCA1/2 mutations. Orthodox Jews (OJ) are an understudied population with unique cultural and religious factors that may influence BRCA1/2 genetic testing uptake. METHODS: Using a mixed-methods approach, we conducted a cross-sectional survey and focus groups among OJ women in New York/New Jersey to explore factors affecting decision-making about BRCA1/2 genetic testing. RESULTS: Among 321 evaluable survey participants, median age was 47 years (range, 25–82); 56% Modern Orthodox and 44% Yeshivish/Chassidish/other; 84% were married; 7% had a personal history of breast or ovarian cancer. Nearly 20% of women had undergone BRCA1/2 genetic testing. Predictors of genetic testing uptake included being Modern Orthodox (odds ratio [OR]=2.31), married (OR=3.49), and having a personal or family history of breast or ovarian cancer (OR=9.74). Focus group participants (N=31) confirmed the importance of rabbinic consultation in medical decision-making and revealed that stigma was a prominent factor in decisions about BRCA1/2 testing due to its potential impact on marriageability. CONCLUSION: In order to increase uptake of BRCA1/2 genetic testing among the OJ population, it is crucial to understand religious and cultural factors, such as stigma and effect on marriageability, and engage religious leaders in raising awareness within the community. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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