| Autor: |
Helena, Malvezzi, Cristine, Dobo, Renee Zon, Filippi, Helen, Mendes do Nascimento, Laura, Palmieri da Silva E Sousa, Juliana, Meola, Carla Azevedo, Piccinato, Sérgio, Podgaec |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
International journal of molecular sciences. 23(5) |
| ISSN: |
1422-0067 |
| Popis: |
Endometriosis causes immunological and cellular alterations. Endometriosis lesions have lower levels of lamin b1 than the endometrium. Moreover, high levels of pro-inflammatory markers are observed in the peritoneal fluid, follicular fluid, and serum in endometriosis lesions. Thus, we hypothesized that the accumulation of senescent cells in endometriosis tissues would facilitate endometriosis maintenance in an inflammatory microenvironment. To study senescent cell markers and the senescence-associated secretory phenotype (SASP) in endometriosis lesions, we conducted a cross-sectional study with 27 patients undergoing video laparoscopy for endometriosis resection and 19 patients without endometriosis. Endometriosis lesions were collected from patients with endometriosis, while eutopic endometrium was collected from patients both with and without endometriosis. Tissues were evaluated for senescence markers (p16 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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