| Autor: |
A V, Eliseenkova, O V, Ktitorova, E S, Kakpakova, T A, Sidorova, A A, Stavrovskaya |
| Rok vydání: |
1999 |
| Předmět: |
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| Zdroj: |
Membranecell biology. 12(4) |
| ISSN: |
1023-6597 |
| Popis: |
In the previous study we have found that Djungarian hamster fibroblasts with high levels of multidrug resistance (MDR) (colchicine-resistance index RI of 1000 to 42000) produce soluble factor(s) communicating MDR to the drug-sensitive cells of the same species by elevating the functional activity of P-glycoprotein (Pgp). Here we have shown that these cells can influence human tumor cells in the same fashion. Rat hepatoma McA RH7777 cells and their colchicine-resistant derivatives are shown to produce a factor with similar effects (induction of MDR and Pgp functional activity in the drug-sensitive cells). These effects seem to depend on the drug resistance level of the donor cells. Our results show that induction of the Pgp-mediated MDR is not species-specific and the tumor cells with intrinsic MDR (arising from the tissue with a high level of Pgp expression) can produce a factor(s) communicating this type of drug resistance to the sensitive cells. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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