| Autor: |
Anton, Forsberg, Simon, Cervenka, Malin, Jonsson Fagerlund, Lars S, Rasmussen, Henrik, Zetterberg, Helena, Erlandsson Harris, Pernilla, Stridh, Eva, Christensson, Anna, Granström, Anna, Schening, Karin, Dymmel, Nina, Knave, Niccolò, Terrando, Mervyn, Maze, Jacqueline, Borg, Andrea, Varrone, Christer, Halldin, Kaj, Blennow, Lars, Farde, Lars I, Eriksson |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
Annals of neurology. 81(4) |
| ISSN: |
1531-8249 |
| Popis: |
Surgery launches a systemic inflammatory reaction that reaches the brain and associates with immune activation and cognitive decline. Although preclinical studies have in part described this systemic-to-brain signaling pathway, we lack information on how these changes appear in humans. This study examines the short- and long-term impact of abdominal surgery on the human brain immune system by positron emission tomography (PET) in relation to blood immune reactivity, plasma inflammatory biomarkers, and cognitive function.Eight males undergoing prostatectomy under general anesthesia were included. Prior to surgery (baseline), at postoperative days 3 to 4, and after 3 months, patients were examined using [Patients showed a global downregulation of gray matter [This study translates preclinical data on changes in the brain immune system after surgery to humans, and suggests an interplay between the human brain and the inflammatory response of the peripheral innate immune system. These findings may be related to postsurgical impairments of cognitive function. Ann Neurol 2017;81:572-582. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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