Highly enantioselective Michael addition of cyclohexanone to nitroolefins catalyzed by pyrrolidine-based bifunctional benzoylthiourea in water

Autor:	Zhen-Yu, Wang, Shu-Rong, Ban, Meng-Chen, Yang, Qing-Shan, Li
Rok vydání:	2016
Zdroj:	Chirality. 28(11)
ISSN:	1520-636X
Popis:	Organocatalysis and aqueous reactions are identified as the focus of the greening of chemistry. Combining these two strategies effectively remains an interesting challenge in organic synthesis. Herein, we used pyrrolidine-based benzoylthiourea 1c to catalyze the asymmetric Michael addition of cyclohexanone to various nitroolefins in water to afford the corresponding compounds in moderate to good yields, and with excellent diastereoselectivities (up to99:1 dr) and enantioselectivities (up to 99% ee).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::21d0dc6759ada92b1f97d711647244c9 https://pubmed.ncbi.nlm.nih.gov/27791318 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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