Response by B cell precursors to pre-B receptor assembly: differences between fetal liver and bone marrow
| Autor: | R R, Hardy, R, Wasserman, Y S, Li, S A, Shinton, K, Hayakawa |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Genes Immunoglobulin Immunoglobulin mu-Chains Recombinant Fusion Proteins B-Lymphocyte Subsets Gene Rearrangement B-Lymphocyte Heavy Chain Immunoglobulin Variable Region Receptors Antigen B-Cell Mice Transgenic Hematopoietic Stem Cells Transfection Mice Liver Antibody Specificity Bone Marrow Hematopoiesis Extramedullary Immune System Animals Humans Cell Lineage Gene Rearrangement B-Lymphocyte |
| Zdroj: | Current topics in microbiology and immunology. 252 |
| ISSN: | 0070-217X |
| Popis: | The expression of different sets of immunoglobulin specificities by fetal and adult B lymphocytes is a longstanding puzzle in immunology. In the past few years it has become clear that production of mu heavy chain and subsequent assembly with surrogate light chain to form the pre-B cell receptor complex is critical to promote development of adult B cell precursors in mouse bone marrow. Recently we found that instead of promoting pre-B cell expansion as in adult bone marrow, this complex inhibits pre-B cell growth in fetal liver, providing a previously unrecognized mechanism for alteration of the B cell repertoire with age. The consequence is very distinct primary repertoires for development of fetal B1 cells and adult bone marrow B2 cells. |
| Databáze: | OpenAIRE |
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