A smart injectable composite hydrogel with magnetic navigation and controlled glutathione release for promoting

Autor: Min-Yu, Chiang, I-Yun, Cheng, Syun-Hong, Chou, Jen-Hao, Tsai, Yong-Ji, Chen, Huai-En, Lu, Shan-Wei, Yang, Shwu-Jen, Chang, San-Yuan, Chen
Rok vydání: 2021
Předmět:
Zdroj: Journal of materials chemistry. B. 9(45)
ISSN: 2050-7518
Popis: Injectable cell-based hydrogels allow surgical operation in a minimally invasive way for articular cartilage lesions but the chondrocytes in the injectable hydrogels are difficultly arrayed and fixed at the site of interest to repair the cartilage tissue. In this study, an injectable hyaluronic acid-polyacrylic acid (HA-pAA) hydrogel was first synthesized using hyaluronic acid-cyclodextrin (HA-CD) and polyacrylic acid-ferrocene (pAA-Fc) to provide cell-delivery and self-healing. To promote the cell fixation and alignment, porous poly(lactic
Databáze: OpenAIRE