[JUN N-TERMINAL KINASES AND THEIR PHARMACOLOGICAL MODULATION OF ISCHE-MIC AND REPERFUSION INJURY OF THE BRAIN]
| Autor: | M V, Shvedova, Ya D, Anfinogenova, I A, Schepetkin, D N, Atochin |
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| Rok vydání: | 2018 |
| Předmět: |
Anthracenes
Acetonitriles Ginsenosides Plant Extracts JNK Mitogen-Activated Protein Kinases Brain Brain Ischemia Neuroprotective Agents Gene Expression Regulation Mitogen-Activated Protein Kinase 10 Quinoxalines Reperfusion Injury Oximes Animals Humans Benzothiazoles Protein Kinase Inhibitors Signal Transduction |
| Zdroj: | Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. 103(3) |
| ISSN: | 0869-8139 |
| Popis: | The article reviews the literature regarding the role of c-Jun-N-terminal kinases (JNK) and its inhibitors in brain damage in the settings of ischemia and reperfusion injury. The implication of JNK in signaling mechanisms involved in ischemia-reperfusion-induced cerebral injury are discussed. Described effects associated with JNK inhibition using synthetic and natural substances in experimental models of ischemic and reperfusion injury of the brain. Results of experimental studies demonstrated that JNK represent promising therapeutic targets for brain protection against ischemic stroke. However, multiple physiologic functions of various JNK family members do not allow for the systemic use of non-specific JNK inhibitors for therapeutic purposes. The authors conclude that the continuous search for selective inhibitors of JNK3 remains an important task. |
| Databáze: | OpenAIRE |
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