[Influence of recombinant interleukin-2 on the course and pathomorphology of intraperitoneal staphylococcal infection in mice]

Autor:	O Ia, Kaufman, S N, Bykovskaia, O V, Shadrin, B V, Shlopov
Rok vydání:	1991
Předmět:	Male Mice Liver Neutrophils Animals Interleukin-2 Female Staphylococcal Infections Lymphocyte Activation Cell Division Injections Intraperitoneal Recombinant Proteins
Zdroj:	Arkhiv patologii. 53(10)
ISSN:	0004-1955
Popis:	Resistance to the lethal doses of the infectious agent (3 DL100) develops in mice 6 days after the intraperitoneal non-lethal dose of staphylococcus in combination with recombinant interleukin-2 (RIL-2). This effect may be due to the activation of T- and B-dependent zones of the regional lymph nodes and spleen, activation and proliferation of the liver stellate reticulo-endotheliocytes, enhancement of the phagocytic activity of the circulating neutrophil granulocytes. These structural and functional mechanisms may be due to both direct RIL-2 effect in combination with an antigenic stimulation and indirect effect through other interleukins produced by lymphocytes activated by RIL-2.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::1bbd0fa8b5b2bc146a9c923bdd641f1d https://pubmed.ncbi.nlm.nih.gov/1793376 Zobrazit plný text záznamu