| Autor: |
M N, Bonev, S, Kozubek, E A, Krasavin, K G, Amirtajev |
| Rok vydání: |
1990 |
| Předmět: |
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| Zdroj: |
International journal of radiation biology. 57(5) |
| ISSN: |
0955-3002 |
| Popis: |
Lambda-prophage induction in repair-deficient and wild-type E. coli strains by heavy ions and gamma-rays has been investigated. The dose dependence of the fraction of induced cells has been measured and its initial slope (lambda-induction potency) determined. The induction by gamma-rays was found to be more efficient in a polA-repair-deficient strain; the value of lambda-induction potency is zero in lexA- and recA- strains. The lambda-induction potency increased with LET for wild-type cells but remained constant in the case of polA- mutant cells. It is suggested that the DNA damage triggering the lambda-prophage induction in the case of ionizing radiation could be a type of DNA single-strand break with complex structure which cannot be repaired by fast repair processes, and which requires a substantial level of energy deposition for induction in a DNA molecule. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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