| Autor: |
Joseph P, Eder, Deborah B, Doroshow, Khanh T, Do, Vicki L, Keedy, Jeffrey S, Sklar, Peter, Glazer, Ranjit, Bindra, Geoffrey I, Shapiro |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
JCO precision oncology. 5 |
| ISSN: |
2473-4284 |
| Popis: |
Tumors with neomorphic mutations in IDH1/2 have defective homologous recombination repair, resulting in sensitivity to poly (ADP-ribose) polymerase (PARP) inhibition. The Olaparib Combination trial is a phase II, open-label study in which patients with solid tumors harboring IDH1/2 mutations were treated with olaparib as monotherapy, with objective response and clinical benefit rates as the primary end points.Ten patients with IDH1/2-mutant tumors by next-generation sequencing were treated with olaparib 300 mg twice daily.Three of five patients with chondrosarcomas had clinical benefit, including one patient with a partial response and two with stable disease lasting7 months. A patient with pulmonary epithelioid hemangioendothelioma had stable disease lasting 11 months. In contrast, clinical benefit was not observed among four patients with cholangiocarcinoma.These results indicate preliminary activity of PARP inhibition in patients with IDH1/2-mutant chondrosarcoma and pulmonary epithelioid hemangioendothelioma. Further studies of PARP inhibitors alone and in combination in this patient population are warranted. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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