| Autor: |
M C, Kammerl, R M, Nüsing, F, Schweda, D, Endemann, M, Stubanus, F, Kees, K J, Lackner, M, Fischereder, B K, Krämer |
| Rok vydání: |
2001 |
| Předmět: |
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| Zdroj: |
Clinical pharmacology and therapeutics. 70(5) |
| ISSN: |
0009-9236 |
| Popis: |
The aim of this study was to examine the effects of highly selective inhibition of cyclooxygenase 2 (COX-2) with rofecoxib on the renin system during long-term stimulation and after short-term stimulation. Six healthy male volunteers received, in a randomized crossover design, a low-sodium diet for days 1 through 9 with or without 25 mg rofecoxib twice daily on days 5 through 9 and, in addition, 20 mg of furosemide intravenously on day 8. Plasma renin activity increased 2 to 3 times over baseline with a low-sodium diet and 5 times over baseline 30 minutes after intravenous furosemide; it was still elevated nearly 5 times on day 9. These effects were completely blocked by rofecoxib. Plasma aldosterone and urinary aldosterone concentrations basically reflected the findings with plasma renin activity. Urinary sodium excretion decreased during a low-sodium diet and increased after intravenous furosemide without being significantly affected by rofecoxib. We have concluded that low-sodium and furosemide-stimulated renin and aldosterone secretion is completely blocked in healthy volunteers during COX-2 inhibition with rofecoxib, suggesting that intact COX-2 is of major importance for stimulation of the renin system under these conditions in man. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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