Report: Cytotoxic flavonoids from the young twigs and leaves of Caesalpinia bonduc (Linn) Roxb
| Autor: | Olubanke Olujoke, Ogunlana, Wen Jun, He, Jun Ting, Fan, Guang Zhi, Zeng, Chang Jiu, Ji, Yu Quing, Zheng, Joseph Abayomi, Olagunju, Afolabi Akintunde, Akindahunsi, Ning Hua, Tan |
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| Rok vydání: | 2015 |
| Předmět: |
Flavonoids
Caesalpinia Plants Medicinal Molecular Structure Paclitaxel Plant Stems Cell Survival Plant Extracts Proton Magnetic Resonance Spectroscopy Chemical Fractionation Antineoplastic Agents Phytogenic Mass Spectrometry Plant Leaves Inhibitory Concentration 50 Structure-Activity Relationship Solvents Humans Carbon-13 Magnetic Resonance Spectroscopy HeLa Cells Phytotherapy |
| Zdroj: | Pakistan journal of pharmaceutical sciences. 28(6) |
| ISSN: | 1011-601X |
| Popis: | The extraction, fractionation and recognition of flavonoids from the ethanolic extract of young twigs and leaves of C. bonduc were carried out. In addition, cytotoxic study of the flavonoids on two cancer cell lines, BGC-823 and HeLa was carried our using sulphorhodamine B assay. Seven flavonoids, six of which are being reported for the first time in this plant, were isolated. Their structures were identified by MS and NMR spectroscopic methods. Petroleum ether, ethyl acetate and water fractions exhibited moderate cytotoxic activity against HeLa cells. Five compounds showed cytotoxic activity against HeLa cell in comparison with Paclitaxel, while only one compound showed a good degree of cytotoxic activity against BGC-823 cell in comparison to Paclitaxel. The results obtained showed a structure - activity relationship. |
| Databáze: | OpenAIRE |
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