Synthesis and characterization of chiral 6-azaspiro[2.5]octanes as potent and selective antagonists of the M

Autor:	Aaron M, Bender, Trever R, Carter, Matthew, Spock, Alice L, Rodriguez, Jonathan W, Dickerson, Jerri M, Rook, Sichen, Chang, Aidong, Qi, Christopher C, Presley, Darren W, Engers, Joel M, Harp, Thomas M, Bridges, Colleen M, Niswender, P Jeffrey, Conn, Craig W, Lindsley
Rok vydání:	2021
Předmět:	Structure-Activity Relationship Dose-Response Relationship Drug Molecular Structure Receptor Muscarinic M4 Humans Muscarinic Antagonists
Zdroj:	Bioorganicmedicinal chemistry letters. 56
ISSN:	1464-3405
Popis:	In this manuscript, we report a series of chiral 6-azaspiro[2.5]octanes and related spirocycles as highly potent and selective antagonists of the muscarinic acetylcholine receptor subtype 4 (mAChR
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::15d71c45fc9259c6cf1b62b08759c9b1 https://pubmed.ncbi.nlm.nih.gov/34838649 Zobrazit plný text záznamu Full Text from ScienceDirect