Maternal virus load and perinatal human immunodeficiency virus type 1 subtype E transmission, Thailand. Bangkok Collaborative Perinatal HIV Transmission Study Group
| Autor: | N, Shaffer, A, Roongpisuthipong, W, Siriwasin, T, Chotpitayasunondh, S, Chearskul, N L, Young, B, Parekh, P A, Mock, C, Bhadrakom, P, Chinayon, M L, Kalish, S K, Phillips, T C, Granade, S, Subbarao, B G, Weniger, T D, Mastro |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Acquired Immunodeficiency Syndrome Infant Newborn Infant Gestational Age Viral Load Delivery Obstetric Thailand Infectious Disease Transmission Vertical CD4 Lymphocyte Count Immunophenotyping Killer Cells Natural Risk-Taking Pregnancy Risk Factors HIV Seropositivity Confidence Intervals HIV-1 Odds Ratio Humans Female Lymphocytes Pregnancy Complications Infectious |
| Zdroj: | The Journal of infectious diseases. 179(3) |
| ISSN: | 0022-1899 |
| Popis: | To determine the rate and risk factors for human immunodeficiency virus (HIV)-1 subtype E perinatal transmission, with focus on virus load, pregnant HIV-infected women and their formula-fed infants were followed prospectively in Bangkok. Of 281 infants with known outcome, 68 were infected (transmission rate, 24.2%; 95% confidence interval, 19.3%-29.6%). Transmitting mothers had a 4.3-fold higher median plasma HIV RNA level at delivery than did nontransmitters (P.001). No transmission occurred at2000 copies/mL. On multivariate analysis, prematurity (adjusted odds ratio [AOR], 4.5), vaginal delivery (AOR, 2.9), low NK cell percentage (AOR, 2.4), and maternal virus load were associated with transmission. As RNA quintiles increased, the AOR for transmission increased linearly from 4.5 to 24.8. Two-thirds of transmission was attributed to virus load10,000 copies/mL. Although risk is multifactorial, high maternal virus load at delivery strongly predicts transmission. This may have important implications for interventions designed to reduce perinatal transmission. |
| Databáze: | OpenAIRE |
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