Behavioural motor effects of MK-801 and DNQX parenteral administration in adult cats: dose-response analysis. Modulatory role of dopaminergic D1 and D2 antagonists on MK-801 induced motor behaviours
| Autor: | E, Motles, C, Infante, M, Gonzalez |
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| Rok vydání: | 2000 |
| Předmět: |
Male
N-Methylaspartate Behavior Animal Dose-Response Relationship Drug Injections Subcutaneous Receptors Dopamine D1 Benzazepines Motor Activity Dopamine D2 Receptor Antagonists Quinoxalines Cats Excitatory Amino Acid Agonists Animals Dopamine Antagonists Female Dizocilpine Maleate Sulpiride Excitatory Amino Acid Antagonists |
| Zdroj: | Archives italiennes de biologie. 138(2) |
| ISSN: | 0003-9829 |
| Popis: | 1. Administration of MK-801 a selective antagonist of the NMDA receptors (50, 100 and 150 micrograms/kg, s.c.) elicited in adult cats ataxia and loss of equilibrium. A dose-response effect was observed. 2. Administration of DNQX, a selective antagonist of the non-NMDA receptors, even with doses 20 times higher than those employed with MK-801, did not produce any behavioural disturbances. 3. Previous injection of SCH 23390, a selective parenteral antagonist of dopamine D1 receptor, reduced significantly the intense ataxic effects of MK-801, while sulpiride only increased the latency of the symptoms. 4. The results are discussed considering the reported interactions between the dopaminergic and glutamatergic systems. |
| Databáze: | OpenAIRE |
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