Immunomodulating action of the 3-phenylcoumarin derivative 6,7-dihydroxy-3-[3',4'-methylenedioxyphenyl]-coumarin in neutrophils from patients with rheumatoid arthritis and in rats with acute joint inflammation

Autor:	Lucinéia Reuse, Albiero, Micássio Fernandes, de Andrade, Larissa Fávaro, Marchi, Ana Paula, Landi-Librandi, Andréa Silva Garcia, de Figueiredo-Rinhel, Camila Andressa, Carvalho, Luciana Mariko, Kabeya, Renê Donizeti Ribeiro, de Oliveira, Ana Elisa Caleiro Seixas, Azzolini, Mônica Tallarico, Pupo, Flávio, da Silva Emery, Yara Maria, Lucisano-Valim
Rok vydání:	2019
Předmět:	Adult Male Neutrophils Anti-Inflammatory Agents Middle Aged Extracellular Traps Arthritis Rheumatoid Immunomodulation Young Adult Neutrophil Infiltration Coumarins Antirheumatic Agents Acute Disease Liposomes Animals Humans Female Rats Wistar Aged
Zdroj:	Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 69(1)
ISSN:	1420-908X
Popis:	To examine whether free (3-PD-5Incorporation of 3-PD-5 into unilamellar liposomes of soya phosphatidylcholine and cholesterol was efficient (57.5 ± 7.9%) and yielded vesicles with low diameter (133.7 ± 18.4 nm), polydispersity index (0.39 ± 0.06), and zeta potential (- 1.22 ± 0.34 mV). 3-PD-5Altogether, the results reported herein indicate that 3-PD-5 is a promising modulator of the early stages of acute joint inflammation that can help to diminish not only excessive neutrophil infiltration in the synovia but also neutrophil activation and its outcomes in RA patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::143a4c6d2cd5f1ae030cf1de138ff205 https://pubmed.ncbi.nlm.nih.gov/31786615 Zobrazit plný text záznamu Full text from SpringerLink