| Autor: |
J D, Hainsworth, L L, Porter, D H, Johnson, K R, Hande, S N, Wolff, R, Birch, G, Enas, F A, Greco |
| Rok vydání: |
1986 |
| Předmět: |
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| Zdroj: |
Cancer treatment reports. 70(3) |
| ISSN: |
0361-5960 |
| Popis: |
Ninety-two patients with advanced non-small cell lung cancer were treated with a combination chemotherapy regimen containing cisplatin, vindesine, and etoposide. Eighteen patients (20%) achieved major responses to therapy (three complete responders and 15 partial responders). Response rates were similar in each histologic subtype. Initial performance status was an important determinant of response; 42% of the patients with a Karnofsky performance status greater than or equal to 70% responded versus 5% of those with a performance status less than 50%. The median duration of partial response was 21 weeks; complete responders had a median response duration of 50 weeks. The median survival for the entire group was 23.5 weeks. Toxicity with this regimen was acceptable; myelosuppression was the major toxic effect and was severe in only 10% of the patients. This regimen produced response rates comparable to those reported with other combinations containing cisplatin. Survival advantage in patients receiving this treatment is not established. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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