[Study of some pharmacological properties of a new adenine derivative]
| Autor: | Iasnetsov, A A, Ozerov, V G, Motin, Vik V, Iasnetsov, S K, Karsanova, Iu V, Ivanov, N A, Chel'naia |
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| Rok vydání: | 2014 |
| Předmět: |
6-Cyano-7-nitroquinoxaline-2
3-dione Male Adenine Action Potentials Receptors N-Methyl-D-Aspartate Drug Administration Schedule Brain Ischemia Rats Tissue Culture Techniques Neuroprotective Agents Picolines Animals Receptors AMPA Dizocilpine Maleate CA1 Region Hippocampal Excitatory Amino Acid Antagonists |
| Zdroj: | Eksperimental'naia i klinicheskaia farmakologiia. 77(10) |
| ISSN: | 0869-2092 |
| Popis: | It is established that the new compound, 9-[2-(4-isopropylphenoxy)ethyl]adenine (9-IPE-adenine) in a dose of 10 mg/kg per day produces neuroprotective effect in rats with brain ischemia model. 9-IPE-adenine decreased the neurologic deficiency 1.2 times more effectively (p0.05) than the reference drug mexidol in analogous dose, and had equal effect with this drug at 25 mg/kg per day on the neurologic deficiency and survival of animals. Electrophysiological studies in hippocampal slices in rats showed that 9-IPE-adenine depressed orthodromic population spikes in CA1 area by 42 ± 4%. Non-competitive antagonist of NMDA receptor complex MK-801, in contrast to D-AP5 (competitive NMDA receptor antagonist) and CNQX (competitive AMPA receptor antagonist), enhanced the depressive effect of the new drug more than two times. These ese results are indicative of the ability of 9-IPE-adenine to modulate the ion channel of NMDA receptor complex. |
| Databáze: | OpenAIRE |
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