Scale-Up of Plasmid DNA Downstream Process Based on Chromatographic Monoliths

Autor: Urh, Černigoj, Aleš, Štrancar
Rok vydání: 2020
Předmět:
Zdroj: Methods in molecular biology (Clifton, N.J.). 2197
ISSN: 1940-6029
Popis: Purification of high-quality plasmid DNA in large quantities is a crucial step in its production for therapeutic use and is usually conducted by different chromatographic techniques. Large-scale preparations require the optimization of yield and homogeneity, while maximizing removal of contaminants and preserving molecular integrity. The advantages of Convective Interaction Media
Databáze: OpenAIRE